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Traditional part

Griffonia (5-HTP source)

Griffonia simplicifolia

Limited human evidenceHigh caution — significant risksInteractions: HighPregnancy: Caution
Benefits summary

A West African seed naturally rich in 5-HTP, used for mood and sleep.

Traditional & historical use

Traditional use (african-diaspora): A West African seed naturally rich in 5-HTP, used for mood and sleep.

Modern claims

A West African seed naturally rich in 5-HTP, used for mood and sleep.

How it may work

Active constituents are under study; evidence ranges from traditional use to preliminary human trials.

Benefit–risk at a glance
Potential benefits
  • A West African seed naturally rich in 5-HTP, used for mood and sleep.
Most credible evidence

Evidence strength: limited human.

Key uncertainties
  • See the evidence level above
Known risks
  • Raises serotonin — dangerous with antidepressants (serotonin syndrome); GI upset.
Who should avoid
  • On antidepressants (SSRIs/SNRIs/MAOIs)
  • Pregnancy
Risks

Raises serotonin — dangerous with antidepressants (serotonin syndrome); GI upset.

Interactions

May interact with prescription medications — review with a clinician if you take any.

Special populations

Use caution in pregnancy, breastfeeding, for children, and with chronic disease unless cleared by a clinician.

Sourcing & growing

Choose reputable, tested suppliers; correct identification is essential for wild-harvested plants.

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